ABSTRACT
La rinitis atrófica es una enfermedad crónica y progresiva de etiología desconocida. Se caracteriza por atrofia de la mucosa nasal y hueso subyacente, dilatación anormal de las cavidades nasales, obstrucción nasal paradójica, y formación de secreciones viscosas y costras secas; produciendo fetidez. Sus manifestaciones clínicas más frecuentes son obstrucción nasal, secreción purulenta, costras nasales y mal olor nasal. Se ha separado en dos entidades: primaria y secundaria. El tratamiento es principalmente conservador, y se han propuesto diversas terapias farmacológicas y quirúrgicas. La rinitis atrófica unilateral es una condición infrecuente, con escasos reportes en la literatura científica. Se puede asociar a la desviación septal, por lo que su corrección quirúrgica es una alternativa terapéutica disponible.
Atrophic rhinitis is a chronic disease of unknown etiology. This condition is characterized by progressive nasal mucosal and underlyng bone atrophy, abnormal widening of the nasal cavities, paradoxical nasal congestion and formation of viscid secretions and dried crusts, leading to a characteristic fetor (ozaena). The main clinical manifestations include nasal obstruction, purulent discharge, daily nasal crusting, nasal dryness and foul smell. It has been divided into two separate entities; primary and secondary. Treatment is mostly conservative, although pharmacological and surgical therapies have been proposed. Unilateral atrophic rhinitis is an uncommon condition, with few reports in the scientific literature. It is associated with septum deviation, so surgical correction is one of the therapeutic options available.
Subject(s)
Humans , Rhinitis, Atrophic/diagnosis , Rhinitis, Atrophic/therapy , Rhinitis, Atrophic/etiology , Rhinitis, Atrophic/pathologyABSTRACT
Atrophic rhinitis is a chronic debilitating nasal mucosal disease of unknown etiology. It is characterized by progressive nasal mucosal atrophy, crusting, fetor and enlargement of the nasal space with paradoxical congestion. The disease induces bilateral nasal obstruction and a persistent foul odour of which the patient and by-standers are painfully aware. Primary atrophic rhinitis has decreased markedly in incidence in the last century. However the prevalence still remains high in developing countries like India. Histopathological features allow this entity to be distinguished from chronic non-specific hypertrophic rhinitis, which may have a cell-mediated immune basis underlying its pathogenesis. Histopathological examination of primary atrophic rhinitis was performed on biopsy material from 30 patients. Mucosal atrophy, squamous metaplasia, and chronic inflammatory cell infiltrate were found to characterize this disease.
Subject(s)
Adolescent , Adult , Female , Humans , Male , Nasal Mucosa/pathology , Rhinitis, Atrophic/pathology , Treatment OutcomeABSTRACT
This study was conducted on 40 cases of primary atrophic rhinitis in comparison with 10 normal control and 10 contact persons. A nasal biopsy had taken aiming to verify the clinical diagnosis and to localize the prostaglandin in this condition using PAP technique in comparison with normal control persons. In this study we found high plasma level of prostaglandin, A.C.T.H and cortisone. But less localization of prostaglandin in the nasal tissue in cases of primary atrophic rhinitis in comparison with normal control persons. This low localization of prostaglandin is due to the unhealthy endothelial cells of the blood vessels that normally synthetize the prostaglandin. The high plasma level of prostaglandin can be explained by the production of prostaglandin from other healthy tissues that triggered by the necrosis. This hight plasma level of prostaglandin results in high level of plasma. A.C.T.H and consequently plasma cortisone. The high level of plasma cortisone may exert inhibitory effect on many immune functions that lowers the local nasal tissue immunity leading to the chronicity of this condition
Subject(s)
Humans , Male , Female , Rhinitis, Atrophic/pathology , Prostaglandins/analysis , Adrenocorticotropic Hormone/analysis , Cortisone/analysis , Hormones/bloodABSTRACT
La rinitis atrófica: oceana es una rinitis crónica, con características clínico-patológicas bien definidas, de incidencia significativa en nuestro medio. Se presenta predominantemente en pacientes de sexo femenino y en etapa de vida sexual activa, por su indudable relación hormonal en la patogenia de esta entidad. Se ha realizado un estudio exhaustivo de 50 casos que se han presentado en el Hospital Loayza durante los últimos 10 años. Se han confeccionado cuadros ilustrativos, distribuyéndolos por grupos etáreos, lugar de nacimiento, procedencia, el tiempo de enfermedad, ocupación, estado civil, uni o bilateralidad de la afección, sintomatología, cuadro clínico, exámenes complementarios, tratamiento médico y quirúrgico, y resultados del tratamiento. Se describe la técnica de Eyries modificada que es la que mejores resultados ofrece a los pacientes. Es sumamente importante su diagnóstico precoz y la aplicación del tratamiento adecuado, así como las medidas preventivas para evitar su propagación y la gran repercusión sicosocial en los pacientes afectados